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An in vitro examination of the impact of polyethylene glycol 400, pluronic P85, and vitamin E d-a-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine

机译：体外检查聚乙二醇400，普朗尼克P85和维生素Ed-α-生育酚聚乙二醇1000琥珀酸酯对离体大鼠肠中P-糖蛋白外流和肠上皮细胞代谢的影响

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The potential inhibitory effects of 3 excipients (polyethylene glycol [PEG] 400, Pluronic P85, and vitamin E d-a-tocopheryl polyethylene glycol 1000 succinate [TPGS]) on the P-glycoprotein (P-gp)-mediated efflux of digoxin (DIG) and cytochrome P450 3A (CYP3A)-mediated metabolism of verapamil (VRP) have been examined in an in vitro permeability model.

机译：3种赋形剂（聚乙二醇[PEG] 400，Pluronic P85和维生素E达生育酚聚乙二醇1000琥珀酸酯[TPGS]）对P-糖蛋白（P-gp）介导的地高辛（DIG）外排的潜在抑制作用在体外通透性模型中已研究了细胞色素P450 3A（CYP3A）介导的维拉帕米（VRP）代谢。

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Johnson, Brendan M.; Charman, William N.; Porter, Christopher J. H.;
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年度 2002
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机译：Pluronic P123和D-α-生育酚基聚乙二醇琥珀酸酯组成的槲皮素负载型聚合物胶束的配制和体外评价
2. Purification of d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) by a temperature-modulated silica gel column chromatography: use of Taguchi method to optimize purification conditions. [J] . Chang Y, Cao Y, Zhang J, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2011,第4期

机译：通过温度调节硅胶柱色谱纯化d-α-生育酚聚乙二醇1000琥珀酸酯（TPGS）：使用Taguchi方法优化纯化条件。
3. d-a-Tocopheryl Polyethylene Glycol 1000 Succinate and a small-molecule Survivin suppressant synergistically induce apoptosis in SKBR3 breast cancer cells [J] . Christiana M. Neophytou, Avgoustinos Mesaritis, Gregoria Gregoriou, Scientific reports. . 2019,第1期

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4. Effect of Tocopheryl Polyethylene Glycol Succinate (TPGS) on Percutaneous Penetration of Minoxidilfrom Water/Ethanol/Polyethylene glycol (PEG) Solutions [C] . Ying-Ku Lin, Ming-Thau Sheu, Hsiu-O Ho Controlled Release Society annual meeting . 2004

机译：生育酚基聚乙二醇琥珀酸酯（TPGS）对米诺地尔从水/乙醇/聚乙二醇（PEG）溶液中渗透的影响
5. An in vitro examination of the impact of polyethylene glycol 400 pluronic P85 and vitamin E d-a-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine [O] . Brendan M. Johnson, William N. Charman, Christopher J. H. Porter 2002

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6. Nanoparticles of Poly(Lactide-Co-Glycolide)-d-a-Tocopheryl Polyethylene Glycol 1000 Succinate Random Copolymer for Cancer Treatment [O] . Yuandong Ma, Yi Zheng, Kexin Liu, 2010

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An in vitro examination of the impact of polyethylene glycol 400, pluronic P85, and vitamin E d-a-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine

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